About Me


My name is Zhen Li. I use single cell genomics technologies to study brain development and diseases. I completed my PhD training at Yale University, under the supervision of Dr. Nenad Sestan. I will periodically update this website with information I found useful or interesting. Thank you for stopping by!


* indicates co-first authorship

Li, Z. , Tyler, W. A., Haydar, T. F. (2020). Lessons from single cell sequencing in CNS cell specification and function. Curr. Opin. in Genet. & Devel. 65(1): 138-143.

Werling, D., Pochareddy, S., Choi, J., An, J., Sheppard, B., Peng, M., Li, Z. et al. (2020). Whole-genome and RNA sequencing reveal variation and transcriptomic coordination in the developing human prefrontal cortex. Cell rep. 31(1):107489

Wang, D., Liu, S., Warrell, J., Won, H., Shi, X., Navarro, F. C. P., Clarke, D., Gu, M., Emani, P., Yang, Y. T. et al. (2018). Comprehensive functional genomic resource and integrative model for the human brain. Science 362:eaat8464

Gandal, M. J., Zhang, P., Hadjimichael, E., Walker, R. L., Chen, C., Liu, S., Won, H., van Bakel, H., Varghese, M., Wang, Y. et al. (2018). Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science 362:eaat8127

Rajarajan, P., Borrman, T., Liao, W., Schrode, N., Flaherty, E., Casiño, C., Powell, S., Yashaswini, C., LaMarca, E. A., Kassim, B. et al. (2018). Revealing the brain's molecular architecture. Science 362:1262-1263

Amiri, A.*, Coppola, G.*, Scuderi, S.*, Wu, F.*, Roychowdhury, T.*, Liu, F., Pochareddy, S. et al. (2018). Transcriptome and epigenome landscape of human cortical development modeled in organoids. Science DOI: 10.1126/science.aat7615

Li M.*, Santpere G.*, Kawasawa Y. I.*, Evgrafov O. V.*, Gulden F. O.*, Pochareddy S.*, Sunkin S. M.*, Li Z.*, Shin Y.* et al. (2018). Integrative functional genomic analysis of human brain development and neuropsychiatric risks. Science DOI: 10.1126/science.aat7615

Fan L., Li Z. and Yuan P. (2018). Wearable Pulse Waveform Measurement System and Method. US Patent App. 15/843,608

Castiglioni V., Faedo A., Onorati M., Bocchi V. D., Li Z., Lennaco, R., Vuono, R., Bulfamante, G. P., Muzio, L., Martino, G., Sestan, N., Barker, R. A. and Cattaneo E. (2018). Dynamic and Cell-Specific DACH1 Expression in Human Neocortical and Striatal Development. Cerebral Cortex. DOI: 10.1093/cercor/bhy092

Mi D.*, Li Z.*, Lim L., Li M., Moissidis M., Yang Y., Gao T., Hu T. X., Pratt T., Price D., Sestan N. and Marín O. (2018). Early emergence of cortical interneuron diversity in the mouse embryo. Science 360(6384). 81-85.

Gu Z., Kalamboglas J., Yoshioka S., Han W., Li Z., Imamura Kawasawa Y., Pochareddy S., Li Z., Liu F., Xu X., Wijeratne S., Ueno M., Blatz E., Salomone J., Kumanogoh A., Rasin M.R., Gebelein B., Weirauch M.T., Sestan N., Martin J.H., and Yoshida Y (2017). Control of species-dependent cortico-motoneuronal connections underlying manual dexterity. Science 357(6349). 400-404.

Yang J., Tanaka Y., Seay M., Li Z., Jin J., Garmire L.X. et al. (2016). Single cell transcriptomics reveals unanticipated features of early hematopoietic precursors. Nuc. Aci. Res., 45(3). 1281 1296.

Onorati M.*, Li Z.*, Liu F.*, Sousa A.M.M.*, Nakagawa N., Li M., Dell’Anno M. T., Goulden F. O., Pochareddy S., Tebbenkamp A. T. N., Han W., Pletikos M. et al. (2016) Zika virus disrupts phospho-tbk1 localization and mitosis in human neuroepithelial stem cells and radial glia. Cell Reports, 16. 2576 2592.

Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, et al. (2015). The PsychENCODE project. Nat. Neurosci. 18. 170712.

Hasan S., Liu L., Triplet J, Li Z. and Mansur D. (2013). The role of postoperative radiation and chemoradiation in Merkel cell carcinoma: a systematic review of the literature. Front. Oncol. 3.